Neurotherapeutics Course
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Training in Neurotherapeutics Discovery and Development

Wednesday, February 19, 2014

7:45 am – 8:30 am

Breakfast

8:30 am – 9:00 am

Overview: The Neurotherapeutics Discovery and Development Process

Course Directors

9:00 am – 10:00 am

Lecture 1: Target and Pathway Interrogation

Douglas Auld, PhD, Novartis Institutes for Biomedical Research

10:00 am – 10:10 am

Break

10:10 am – 11:10 am

Lecture 2: Biology Basics for Identifying Hits

William Janzen, BS, University of North Carolina, Chapel Hill

11:10 am – 12:10 pm

Lecture 3: Moving from Hit to Lead to Clinical Candidate

James Barrow, PhD, Johns Hopkins School of Medicine

12:10 pm – 1:30 pm

Lunch (Students paired with mentors)

1:30 pm – 2:30 pm

Lecture 4: Medicinal Chemistry

Craig Lindsley, PhD, Vanderbilt University Medical Center

2:30 pm – 3:30 pm

Lecture 5: Alternative Approaches to Lead Generation

Sam Enna, PhD, University of Kansas

3:30 pm – 3:45 pm

Break

3:45 pm – 5:30 pm

Engagement Exercise 1: Clarify vision statement and begin to develop the components of mock translations grant application

5:30 pm – 6:15 pm

Networking Reception

6:15 pm – 7:00 pm

Dinner

7:00 pm – 8:15 pm

After Dinner Talk: Drug Discovery

Solomon Snyder, MD, DSc, DPhil, Johns Hopkins University

Thursday, February 20, 2014

7:15 am – 8:00 am

Breakfast

8:00 am – 9:00 am

Lecture 6: ADME

Kennan Marsh, PhD, AbbVie

9:00 am – 10:00 am

Lecture 7: Formulation and Route of Administration

Heike Wulff, PhD, University of California, Davis

10:00 am – 10:10 am

Break

10:10 am – 11:10 am

Lecture 8: Preclinical Proof-Concept / Target Engagement Studies

Kalpana Merchant, PhD, Eli Lilly and Company

11:10 am – 12:10 pm

Lecture 9: Toxicology

Adaline Smith, Ironwood Pharmaceuticals

12:10 pm – 1:30 pm

Lunch (Responsible conduct of research exercise)

1:30 pm – 1:45 pm

Break

1:45 pm – 5:45 pm

Engagement Exercise 2: Round-Robin – Students interact individually with each subject expert

5:45 pm – 6:30 pm

Networking Reception – ASENT Annual Meeting

6:30 pm – 7:30 pm

ASENT Annual Meeting Dinner

7:30 pm – 9:00 pm

Reserved for students to prepare mock translation grant applications; mentors available

Friday, February 21, 2014

7:15 am – 8:00 am

Breakfast

8:00 am – 9:00 am

Lecture 11: Experimental Medicine and Biomarkers

Ajay Verma, MD, PhD, Biogen Idec

9:00 am – 10:00 am

Lecture 10: IND Enabling Studies and Preparation of the IND

William Bracken, PhD, DABT, AbbVie

10:00 am – 10:10 am

Break

10:10 am – 11:10 am

Lecture 12: Interacting with the FDA

Russell Katz, MD, FDA Center for Drug Evaluation & Research

11:10 am – 12:10 pm

Lecture 13: Intellectual Property

Kenneth A. Weber, PhD, JD, Partner, Kilpatrick Townsend & Stockton LLP

12:10 pm – 2:00 pm

Lunch

2:15 pm – 6:00 pm

Pipeline Session -ASENT 15th Annual Meeting

Brief presentations on ongoing corporate and academic neurotherapeutic R&D projects

6:30 pm – 8:30 pm

Restaurant Dinner

Saturday, February 22, 2014

7:15 am – 8:00 am

Breakfast

8:00 am – 9:00 am

Lecture 14: Funding Academic Drug Discovery Research

Rebecca Farkas, PhD, NIH/NINDS

9:00 am – 10:15 am

Engagement Exercise 3: Student Presentations – Description of mock translational grant application followed by critique

10:15 am – 10:30 am

Break

10:30 am – 11:45 am

Engagement Exercise 3: Continued

11:45 am – 12:00 pm

Lecture 15: Where Do We Go From Here?  Presentation of Plan for Continued Mentoring, Engagement and Course Evaluation over Two-Year Period

Course Directors

12:00 pm

Adjourn