This is a preliminary program and is subject to change and completion.
Course Schedule of Activities
Tuesday, March 14, 2023
7:15 am – 8:00 am
Check-in and Continental Breakfast
8:00 am – 8:20 am
Overview: The Neurotherapeutics Discovery and Development Process
Michael A. Rogawski, MD, PhD, University of California, Davis
8:20 am – 9:40 am
Session 1: Target and Pathway Interrogation
James Inglese, PhD, National Center for Advancing Translational Sciences, NIH
9:40 am – 10:30 am
Session 2: Biology Basics for Identifying Hits
William Janzen, BS, Ribometrix, Inc.
Ballroom B
10:30 am – 10:50 am
Break
10:50 am – 11:40 am
Session 3: Moving from Hit to Lead to Clinical Candidate
James Barrow, PhD, Johns Hopkins School of Medicine
Ballroom B
11:40 am – 12:30 pm
Session 4: Antibody-Based Therapies
Gai Ayalon, PhD, Ultragenyx Pharmaceuticals
Ballroom B
12:30 pm – 1:30 pm
Lunch
Meet with Mentors
Ballrooms A & C
Conference Rooms A & C
1:30 pm – 2:20 pm
Session 5: Intellectual Property
Jeffrey W. Childers, JD, PhD, Casimir Jones
Ballroom B
2:20 pm – 3:10 pm
Session 6: ADME
Kennan Marsh, PhD, AbbVie
Ballroom B
3:10 pm – 4:20 pm
Break
4:20 pm – 4:35 pm
Engagement Exercise: Introduction to Round Robbins
Ballroom B
4:35 pm – 5:35 pm
Engagement Exercise: Round Robin Day 1
Ballfooms A & C / Conference Rooms A & B
5:35 pm – 6:00 pm
Break
6:00 pm – 8:00 pm
Dinner
Mondavi Center
7:15 am – 8:00 am
Check-in and Continental Breakfast
8:00 am – 8:20 am
Overview: The Neurotherapeutics Discovery and Development Process
Michael A. Rogawski, MD, PhD, University of California, Davis
8:20 am – 9:40 am
Session 1: Target and Pathway Interrogation
James Inglese, PhD, National Center for Advancing Translational Sciences, NIH
9:40 am – 10:30 am
Session 2: Biology Basics for Identifying Hits
William Janzen, BS, Ribometrix, Inc.
Ballroom B
10:30 am – 10:50 am
Break
10:50 am – 11:40 am
Session 3: Moving from Hit to Lead to Clinical Candidate
James Barrow, PhD, Johns Hopkins School of Medicine
Ballroom B
11:40 am – 12:30 pm
Session 4: Antibody-Based Therapies
Gai Ayalon, PhD, Ultragenyx Pharmaceuticals
Ballroom B
12:30 pm – 1:30 pm
Lunch
Meet with Mentors
Ballrooms A & C
Conference Rooms A & C
1:30 pm – 2:20 pm
Session 5: Intellectual Property
Jeffrey W. Childers, JD, PhD, Casimir Jones
Ballroom B
2:20 pm – 3:10 pm
Session 6: ADME
Kennan Marsh, PhD, AbbVie
Ballroom B
3:10 pm – 4:20 pm
Break
4:20 pm – 4:35 pm
Engagement Exercise: Introduction to Round Robbins
Ballroom B
4:35 pm – 5:35 pm
Engagement Exercise: Round Robin Day 1
Ballfooms A & C / Conference Rooms A & B
5:35 pm – 6:00 pm
Break
6:00 pm – 8:00 pm
Dinner
Mondavi Center
Wednesday, March 15, 2023
7:15 am – 8:00 am
Continental Breakfast
8:00 am – 8:50 am
Session 7: Formulation and Routes of Administration
Maureen Donovan, PhD, University of Iowa
Ballfoom B
8:50 am – 9:40 am
Session 8: Alternative Routes of Administration
James Cloyd III, PharmD, University of Minnesota.
Ballroom B
9:40 am – 10:00 am
Break
10:00 am – 10:50 am
Session 9: Alternative Approaches to Lead Generation
Sam J. Enna, PhD, University of Kansas
Ballroom B
10:50 pm – 11:40 pm
Session 10: Toxicology
Adaline Smith, PhD, DABT, Adagen Preclinical Solutions
Ballroom B
11:40 pm – 1:50 pm
Lunch
Responsible Conduct of Research Exercise
Ballrooms A & C
Conference Rooms A & C
1:50 pm – 2:40 pm
Session 11: IND Enabling Studies and Preparation of the IND
Ted Spack, PhD, Vector Biosciences
Ballroom B
2:40 pm – 3:10 pm
Session 12: Academic Drug Discovery Vignette – A story of "Bench to (Almost) Bedside"
Barbara Slusher, PhD, MAS, Johns Hopkins (Virtual)
Ballroom B
3:10 pm – 3:25 pm
Engagement Exercise: Introduction to Round Robbins
Ballroom B
3:25 pm – 3:45 pm
Break
3:45 pm – 4:45 pm
Engagement Exercise: Round Robin Day 2
Ballfooms A & C / Conference Rooms A & B
4:45 pm – 6:00 pm
Break
6:00 pm – 8:00 pm
Dinner
7:15 am – 8:00 am
Continental Breakfast
8:00 am – 8:50 am
Session 7: Formulation and Routes of Administration
Maureen Donovan, PhD, University of Iowa
Ballfoom B
8:50 am – 9:40 am
Session 8: Alternative Routes of Administration
James Cloyd III, PharmD, University of Minnesota.
Ballroom B
9:40 am – 10:00 am
Break
10:00 am – 10:50 am
Session 9: Alternative Approaches to Lead Generation
Sam J. Enna, PhD, University of Kansas
Ballroom B
10:50 pm – 11:40 pm
Session 10: Toxicology
Adaline Smith, PhD, DABT, Adagen Preclinical Solutions
Ballroom B
11:40 pm – 1:50 pm
Lunch
Responsible Conduct of Research Exercise
Ballrooms A & C
Conference Rooms A & C
1:50 pm – 2:40 pm
Session 11: IND Enabling Studies and Preparation of the IND
Ted Spack, PhD, Vector Biosciences
Ballroom B
2:40 pm – 3:10 pm
Session 12: Academic Drug Discovery Vignette – A story of "Bench to (Almost) Bedside"
Barbara Slusher, PhD, MAS, Johns Hopkins (Virtual)
Ballroom B
3:10 pm – 3:25 pm
Engagement Exercise: Introduction to Round Robbins
Ballroom B
3:25 pm – 3:45 pm
Break
3:45 pm – 4:45 pm
Engagement Exercise: Round Robin Day 2
Ballfooms A & C / Conference Rooms A & B
4:45 pm – 6:00 pm
Break
6:00 pm – 8:00 pm
Dinner
Thursday, March 16, 2023
7:15 am – 8:00 am
Continental Breakfast
8:30 am – 8:50 am
Session 13:: Antisense Oligonucleotides
Gene Liau, PhD, Stoke Therapeutics
Ballfoom B
8:50 am – 9:40 am
Session 14: Clinical Considerations in the Non-
Clinical Phase of Drug Discovery and Development
James J. Vornov, MD, PhD, Johns Hopkins School of
Medicine and Medpace
Ballroom B
9:40 am – 10:00 am
Break
10:00 am – 10:50 am
Session 15: Rigor in Translational Drug
Discovery and Development
Shai Silberberg, PhD, NINDS (Virtual)
Ballroom B
10:50 am – 11:40 am
Session 16: Funding Academic Drug Discovery Research
Charles L.Cywin, PhD, NINDS (Virtual)
Ballroom B
11:40 am – 1:00 pm
Lunch
1:00 pm – 2:30 pm
Engagement Exercise: Round Robbin Day 3
Ballrooms A & C / Conference Rooms A & B
2:30 pm – 4:30 pm
Work on Presentation
Mentors available for discussion
Ballrooms A & C / Conference Rooms A & B
4:30 pm – 6:00 pm
Break
6:00 pm – 8:00 pm
Dinner
Mondavi Center
7:15 am – 8:00 am
Continental Breakfast
8:30 am – 8:50 am
Session 13:: Antisense Oligonucleotides
Gene Liau, PhD, Stoke Therapeutics
Ballfoom B
8:50 am – 9:40 am
Session 14: Clinical Considerations in the Non-
Clinical Phase of Drug Discovery and Development
James J. Vornov, MD, PhD, Johns Hopkins School of
Medicine and Medpace
Ballroom B
9:40 am – 10:00 am
Break
10:00 am – 10:50 am
Session 15: Rigor in Translational Drug
Discovery and Development
Shai Silberberg, PhD, NINDS (Virtual)
Ballroom B
10:50 am – 11:40 am
Session 16: Funding Academic Drug Discovery Research
Charles L.Cywin, PhD, NINDS (Virtual)
Ballroom B
11:40 am – 1:00 pm
Lunch
1:00 pm – 2:30 pm
Engagement Exercise: Round Robbin Day 3
Ballrooms A & C / Conference Rooms A & B
2:30 pm – 4:30 pm
Work on Presentation
Mentors available for discussion
Ballrooms A & C / Conference Rooms A & B
4:30 pm – 6:00 pm
Break
6:00 pm – 8:00 pm
Dinner
Mondavi Center
Friday, March 17, 2023
7:15 am – 8:00 am
Continental Breakfast
8:00 am – 8:15 am
Student Presentations – Introduction
8:15 am – 11:30 am
Engagement Exercise: Student Presentations
11:30 am – 12:00 noon
Conclusion
Course Evaluations.
Lunch
12:00 noon
Adjournment
7:15 am – 8:00 am
Continental Breakfast
8:00 am – 8:15 am
Student Presentations – Introduction
8:15 am – 11:30 am
Engagement Exercise: Student Presentations
11:30 am – 12:00 noon
Conclusion
Course Evaluations.
Lunch
12:00 noon
Adjournment
